Application In Pharmaceutical Industry
This technical bulletin outlines the various applications and uses of CDD 5000 in the Pharmaceutical Industry. Notably, F&B and Pharmaceutical are the only two industries governed under the most stringent regulatory guidelines, primarily because they have a direct correlation with human health and human consumption of substances.
Moreover, like in most industries even in the pharmaceutical industry water plays a crucial role as a utility and as a Raw Material. The bacteriological parameters are verified and checked on an hourly or daily basis. Additionally, in the pharmaceutical industry, common infestations such as E. coli, Coliforms, and basic groups like Pseudomonas, Salmonella, Legionella, Molds, and Spores are frequently encountered.
The cause of this would be source water contamination. Typically, the supply of the source or process water may be from Tap water, River, Borewell, Water supplied by the Industry association or from Tankers.
Due to a factor called immunity building, the bacteria present at the contact surface of various equipment, pumps, etc… or in the water develop a resistance towards the commonly used biocides. Consequently, they start developing biofilm which acts as a breeding zone for the bacteria to prosper. As a result, this makes the entire system contaminated.
Therefore, despite the presence of a biocide in the water, the analysis may still show a positive count. Increasing the dose of the biocide however, does not yield stable results.
In a normal course a water treatment system consists of the following steps in a sequential manner.
- PSF filter.
- Activated carbon filter.
- Water softener in case of hard water.
- DM water generation through, Anionic, cationic & mixed bed resins.
- Ultra filteration.
- Reverse osmosis
The water entering the ACF or softener is dechlorinated with the help of SMBS and subsequently, the water passing through further units does not have a biocide to avoid bacterial contamination. And use of another chemical on shock dosing will damage the membranes and resins.
In contrast, CDD 5000 does not damage the resins or membrane of the RO. Additionally, membranes of several types excluding cellulosic membranes have shown compatibility with CDD 5000 at user concentration levels & for sanitation at the CIP level.
CDD 5000 has following applications in Pharmaceutical & Biotech industry
- Process water/Raw water treatment.
- Cleaning in Place (CIP) and Sanitizing Operations
- For viruses, bacteria, Mold removal
- For Membrane & resin sanitation.
- For air sanitation.
- Sanitation of Raw & processed water tanks.
- Wastewater treatment
